Information for
Providers

Pharmacists

What

Creating a medication safety platform to protect against high-risk medications and medication regimens. The pharmacy can enhance their current service offerings to incorporate personalized medicine and risk analysis through targeted genetic testing. This enhanced PGx service can strengthen their client and provider relationships within the community.

How

By adding pharmacogenomic testing into the pharmacy we empower the pharmacist to manage chronic disease conditions while driving medication adherence.

Providers

What

A genetic test that profiles a patient’s genes to determine how he or she reacts to specific medication. Results of this pharmacogentic testing provide both patient and provider with a comprehensive and actionable report that allows providers to create individualized treatment and prevention plans.

How

A simple buccal swab is all that’s needed to test genetic markers and molecular data to create a comprehensive, actionable report for you to evaluate and determine the most effective treatment pathway for your patients.

What is Pharmacogenomics (PGx)?

Pharmacogenomics is the study of genetic differences in metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.

Why PGx (Pharmacogenomic) testing?

      1. Adverse Drug Reactions are on the rise in the US. There are over 100,000 deaths and 2 Million adverse drug events in the US annually. Many of these could be prevented if the physician knew the patient could not tolerate certain medicationsADR’s are now the 4th leading cause of death in the US
      2. Most physicians are not familiar with RAW genetic results – PGx testing and results enable the physician to determine which
        medications to prescribe based on the individual
      3. Enhancing Patient Outcomes through molecular screening
        1. The average post-acute care nursing home patient is on 15.2 medications.
        2. The costs have become unsustainable
        3. Many of the drugs are offsetting side effects not targeting clinical efficacy
        4. Over-prescribing is a band-aid approach to eliminate readmissions to the hospitals
      4. Physicians are under intense pressure to act responsibly and often conservatively

How do you determine who should be tested?

Evidence-based protocols based on medical necessity assist and guide physicians to determine which patients to test based on the following criteria:

Patient Type Criteria
New Patients No treatment history for the condition/medication
All Patients History of medication sensitivity or ADEs to current meds.
All Patients Failure of previous medications to provide therapeutic value
All Patients On multiple medications
All Patients Experiencing unpleasant or intolerable side effects of current meds
All Patients Suspected of abusing or diverting medication

How does PGx testing benefit the patient?

      • Not everyone responds to a drug or medication in the same way
      • Each individual has their own unique genetic makeup, which affects the way their bodies respond to a disease and treatment
      • PGx uses information about a person’s genetic make up to choose the drugs and drug doses that are likely to work best for that person as well as determining the proper drug-to-drug combinations

How does PGx testing benefit the physician?

      1. Improve & revolutionize patient care though PGx testing
      2. Actionable data at the point of care
      3. Tools to follow medical necessity protocols and track outcomes
      4. Incorporating personalized medicine techniques is a competitive advantage
      5. Provides ancillary revenue source for your practice (Precision Genetics LCS Model)

What gene panels do we offer? (See attached PGx panel list)

      1. Pain
      2. Psych
      3. Cardio
      4. Comprehensive

What products do we offer today?

Precision Genetics (PG) is a molecular diagnostic laboratory located in Greenville, SC specializing in pharmacogenetics. Today, PG focuses their sales and marketing efforts on the pain management, psychiatric, cardiovascular markets, primary care, internal medicine, family practice, post-acute care, and women’s health for (comprehensive medication management).

Why Precision?

  1. PG offers a complete pain management, psychiatric, cardiac panel, and comprehensive with all of the most clinically relevant drugs as related to genetics.
  2. Our competitors may test more genes or different genes, but according to the latest and most credible evidence available, PG is using the most clinically relevant data that verifies clinical utilization and evidence based medicine.
  3. PG also offers Drug-to-Drug Interaction test based SOLELY on a patient’s own genetics. Some of our competition has a DDI section on their report but it is not genetically based. It is simply information you can obtain off of the internet.
  4. PG will turnaround the patient results in 72 hours or less.
  5. PG can email results, fax results directly to physician’s EMR, or give the physician access to their patient report via our web portal.
  6. PG has partnered with Coriell Life Sciences utilizing our best-in-class reporting and interpretation software – GeneDose. GeneDose
    combines an analysis of the patient’s DNA by Precision Genetics, identifying relevant variants that are informative for medication efficacy, safety, and dosing. Our report produces immediate actionable clinical guidance regarding safer and more effective medications and dosages for the patient.
  7. PG and Coriell also produce therapeutic decision support information for drug-to-drug interactions, drug regimens, indications, demographics, and lifestyle indicators through our real-time GeneDose LIVE platform.

Targets?

  1. Pain Management Clinics that do NOT have a complex CLIA lab. Why? Our first panel on the requisition form is geared toward pain management drugs. Pain clinics are under intense scrutiny to not overprescribe. Running this test alleviates some liability for the physician so that they can show they have done all of the due diligence they have available.
  2. Rheumatology / Arthritis Clinics – Should be a BIG ONE! Why? First and most importantly, the competition is NOT calling on them. It is very low hanging fruit. Our panel offers Celebrex in the genetic section (which is a top med to be prescribed for inflammation). These docs also write a lot of pain meds for their chronic arthritis patients who can’t get relief.
    *In addition to this, the Drug-Drug Interaction section of our test offering has many NSAIDs on it (NSAIDS are non-steroidal anti- inflammatory drugs) drugs like Ibuprofen and Naproxen. RA docs LOVE prescribing these.
  3. Psychiatry – The 2nd panel we offer is geared toward mental health. It covers pretty much every antidepressant on the market. It also covers anti-psychotics and other mental health drugs
  4. General Practitioners – GP’s prescribe probably more antidepressants than psychiatrists do. They also write a lot of pain management drugs. Further, many of their patients are on MULTIPLE meds at one time and the Drug-Drug Interaction portion of our test offering is great for those patients.
  5. OB/GYN – OB’s write a large number of scripts for antidepressants. Many women use their OB as their general practitioner.
  6. Cardiologists – Our newest panel focuses on the reimbursement patterns in the CV world. Although the panel is being modestly
    paid by Medicare (specifically related to Plavix), the private sector reimbursements are substantial.

ARE YOU READY TO GET PERSONAL?

Personalized medicine is at your fingertips with a simple cheek swab. What you provide your patients today can help them well into the future.